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B7: Controlling neural wave dynamics by nonlocal and time-delayed feedback
Principal investigator*:
Prof. Dr. Eckehard Schöll, PhD [1]
Project
summary:
We aim to investigate theoretically how
internal control mechanisms in the brain prevent the emergence of
nonlinear excitation waves based on reaction-diffusion, i.e.,
spreading depression (SD), and how, if they fail, SD waves can be
suppressed by external feedback control. SD is a pathological
activity of the human cortex, and is related to migraine, stroke, and
various kinds of brain injury. Control of SD by external
neuromodulation is of clinical importance because SD causes transient
neurological deficits and subsequently headache (migraine) or
permanent brain damage (stroke and brain injury).
*from
01.01.2011 - 30.09.2012: Dr. Markus Dahlem [2], Prof. Dr. Eckehard
Schöll, PhD [3]
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