### Inhalt des Dokuments

# Statistische Physik weicher Materie und biologischer Systeme

Die Arbeitsgruppe bearbeitet ein breites Spektrum von Projekten aus den Bereichen der statistischen Physik weicher Materie und biologischer Systeme. Neben Frage- stellungen im thermischen Gleichgewicht werden vor allem Systeme untersucht, die durch externe Felder im Nichtgleichgewicht gehalten werden oder von sich heraus einen Nichtgleichgewichtszustand annehmen, wie zum Beispiel aktive Brownsche Teilchen. Dabei lassen wir uns von hochaktuellen Forschungsgebieten wie der Mikrofluidik und Biofluiddynamik leiten.

Derzeit ist ein Schwerpunkt unserer Forschung die aktive Bewegung in künstlichen und in biologischen Systemen. Dabei geht es um das Verständnis von Design- prinzipen zur Generierung aktiver Bewegung, um deren generische Eigenschaften und um kollektives Verhalten.

Unser Themenspektrum umfasst:

- Weiche Materie: insbes. Flüssigkristalle, kolloidale Dispersionen, (Bio-)Polymere
- Strukturbildung weicher Materie an Grenzflächen
- Weiche Materie und biologische Systeme im Nichtgleichgewicht, Mikrofluidik
- Biofluiddynamik und Fortbewegung von Mikroorganismen, aktive Bewegung
- Biomimetische Materialien und Biomechanik

# Aktuelles

**Ausschreibung: Studentische Hilfskraft mit 40 Monatsstunden**

Seminar

Die AG Stark bietet im Sommersemester 2022 das Seminar

Themen und Methoden der Statistischen Mechanik weicher Materie und biologischer Systeme an.

Auf der ISIS-Seite finden Sie aktuelle Informationen und den Zoom-Link zur Online-Veranstaltung**Bitte melden Sie sich über das SAP-System an, um Modulpunkte erhalten zu können.**

Weitere Neuigkeiten:

**Q&A with Prof. Holger Stark, Editor-in-Chief of EPJ E**

Link to the Springer website

**Prof. Stark bietet folgende Prüfungstermine an**- Donnerstag, 05.05.2022
- Donnerstag, 02.06.2022

** Bitte melden Sie sich direkt über das SAP-Sytem zur Prüfung an!**

**Brennpunkt-Artikel im Physik Journal:**

Die Körperform macht's

Holger Stark

Physik Journal

**On the cross-streamline lift of microswimmers in viscoelastic flows**

**by Akash Choudhary and Holger Stark**

The current work studies the dynamics of a microswimmer in pressure-driven flow of a weakly viscoelastic fluid. Employing a second-order fluid model, we show that a self-propelling swimmer experiences a viscoelastic swimming lift in addition to the well-known passive lift that arises from its resistance to shear flow. Using the reciprocal theorem, we evaluate analytical expressions for the swimming lift experienced by neutral and pusher/puller-type swimmers and show that they depend on the hydrodynamic signature associated with the swimming mechanism. We find that, in comparison to passive particles, the focusing of neutral swimmers towards the centerline can be significantly accelerated, while for force-dipole swimmers no net modification in cross-streamline migration occurs.

**How inertial lift affects the dynamics of a microswimmer in Poiseuille flow**

**by Akash Choudhary, Subhechchha Paul, Felix Rühle, and Holger Stark**

The transport of motile microorganisms is strongly influenced by fluid flows that are ubiquitous in biological environments. Here we demonstrate the impact of fluid inertia. We analyze the dynamics of a microswimmer in pressure-driven Poiseuille flow, where fluid inertia is small but non-negligible. Using perturbation theory and the reciprocal theorem, we show that in addition to the classical inertial lift of passive particles, the active nature generates a ‘swimming lift’, which we evaluate for neutral and pusher/puller-type swimmers. Accounting for fluid inertia engenders a rich spectrum of complex dynamics including bistable states, where tumbling coexists with stable centerline swimming or swinging. The dynamics is sensitive to the swimmer’s hydrodynamic signature and goes well beyond the findings at vanishing fluid inertia. Our work will have non-trivial implications on the transport and dispersion of active suspensions in microchannels.

**Gyrotactic cluster formation of bottom-heavy squirmers**

**by Felix Rühle, Arne W. Zantop and Holger Stark**

Squirmers that are bottom-heavy experience a torque that aligns them along the vertical so that they swim upwards. In a suspension of many squirmers, they also interact hydrodynamically via flow fields that are initiated by their swimming motion and by gravity. Swimming under the combined action of flow field vorticity and gravitational torque is called gyrotaxis. Using the method of multi-particle collision dynamics, we perform hydrodynamic simulations of a many-squirmer system floating above the bottom surface. Due to gyrotaxis they exhibit pronounced cluster formation with increasing gravitational torque. The clusters are more volatile at low values but compactify to smaller clusters at larger torques. The mean distance between clusters is mainly controlled by the gravitational torque and not the global density. Furthermore, we observe that neutral squirmers form clusters more easily, whereas pullers require larger gravitational torques due to their additional force-dipole flow fields. We do not observe clustering for pusher squirmers. Adding a rotlet dipole to the squirmer flow field induces swirling clusters. At high gravitational strengths, the hydrodynamic interactions with the no-slip boundary create an additional vertical alignment for neutral squirmers, which also supports cluster formation.

**Droplets on substrates with oscillating wettability**

**by Josua Grawitter and Holger Stark**

In recent decades novel solid substrates have been designed which change their wettability in response to light or an electrostatic field. Here, we investigate a droplet on substrates with oscillating uniform wettability by varying minimum and maximum contact angles and frequency. To simulate this situation, we use our previous work [Grawitter and Stark, Soft Matter, 2021, **17**, 2454], where we implemented the boundary element method in combination with the Cox–Voinov law for the contact-line velocity, to determine the fluid flow inside a droplet. After a transient regime the droplet performs steady oscillations, the amplitude of which decreases with increasing frequency. For slow oscillations our numerical results agree well with the linearized spherical-cap model. They collapse on a master curve when we rescale frequency by a characteristic relaxation time. In contrast, for fast oscillations we observe significant deviations from the master curve. The decay of the susceptibility is weaker and the phase shift between oscillations in wettability and contact angle stays below the predicted π/2. The reason becomes obvious when studying the combined dynamics of droplet height and contact angle. It reveals non-reciprocal shape changes during one oscillation period even at low frequencies due to the induced fluid flow inside the droplet, which are not captured by the spherical-cap model. Similar periodic non-reciprocal shape changes occur at low frequencies when the droplet is placed on an oscillating nonuniform wettability profile with six-fold symmetry. Such profiles are inspired by the light intensity pattern of Laguerre–Gauss laser modes. Since the non-reciprocal shape changes induce fluid circulation, which is controllable from the outside, our findings envisage the design of targeted microfluidic transport of solutes inside the droplet.

Soft Matter **17**, 9469-9479 (2021)

**Steering droplets on substrates using moving steps in wettability**

**by Josua Grawitter and Holger Stark**

Droplets move on substrates with a spatio-temporal wettability pattern as generated, for example, on light-switchable surfaces. To study such cases, we implement the boundary-element method to solve the governing Stokes equations for the fluid flow field inside and on the surface of a droplet and supplement it by the Cox–Voinov law for the dynamics of the contact line. Our approach reproduces the relaxation of an axisymmetric droplet in experiments, which we initiate by instantaneously switching the uniform wettability of a substrate quantified by the equilibrium contact angle. In a step profile of wettability the droplet moves towards higher wettability. Using a feedback loop to keep the distance or offset between step and droplet center constant, induces a constant velocity with which the droplet surfs on the wettability step. We analyze the velocity in terms of droplet offset and step width for typical wetting parameters. Moving instead the wettability step with constant speed, we determine the maximally possible droplet velocities under various conditions. The observed droplet speeds agree with the values from the feedback study for the same positive droplet offset.

Soft Matter **17**, 2454-2467 (2021)

**Instability of a Liquid Sheet with Viscosity Contrast in Inertial Microfluidics**

**Kuntal Patel and Holger Stark**

Flows at moderate Reynolds numbers in inertial microfluidics enable high throughput and inertial focusing of particles and cells with relevance in biomedical applications. In the present work, we consider a viscosity-stratified three-layer flow in the inertial regime. We investigate the interfacial instability of a liquid sheet surrounded by a density-matched but more viscous fluid in a channel flow. We use linear stability analysis based on the Orr–Sommerfeld equation and direct numerical simulations with the lattice Boltzmann method (LBM) to perform an extensive parameter study. Our aim is to contribute to a controlled droplet production in inertial microfluidics. In the first part, on the linear stability analysis we show that the growth rate of the fastest growing mode ξ* increases with the Reynolds number Re and that its wavelength λ* is always smaller than the channel width w for sufficiently small interfacial tension Γ. For thin sheets we find the scaling relation ξ*∝mt2.5s, where m is viscosity ratio and ts the sheet thickness. In contrast, for thicker sheets ξ* decreases with increasing ts or m due to the nearby channel walls. Examining the eigenvalue spectra, we identify Yih modes at the interface. In the second part on the LBM simulations, the thin liquid sheet develops two distinct dynamic states: waves traveling along the interface and breakup into droplets with bullet shape. For smaller flow rates and larger sheet thicknesses, we also observe ligament formation and the sheet eventually evolves irregularly. Our work gives some indication how droplet formation can be controlled with a suitable parameter set {λ,ts,m,Γ,Re}.

Eur. Phys. J. E **44**, 144 (2021)

**Oscillatory active microrheology of active suspensions**

**Milos Knezevic, Luisa E. Aviles Podgurski and Holger Stark**

Using the method of Brownian dynamics, we investigate the dynamic properties of a 2d suspension of active disks at high Péclet numbers using active microrheology. In our simulations the tracer particle is driven either by a constant or an oscillatory external force. In the first case, we find that the mobility of the tracer initially appreciably decreases with the external force and then becomes approximately constant for larger forces. For an oscillatory driving force we find that the dynamic mobility shows a quite complex behavior—it displays a highly nonlinear behavior on both the amplitude and frequency of the driving force. In the range of forces studied, we do not observe a linear regime. This result is important because it reveals that a phenomenological description of tracer motion in active media in terms of a simple linear stochastic equation even with a memory-mobility kernel is not appropriate, in the general case.

**Multi-particle collision dynamics with a non-ideal equation of state. II. Collective dynamics of elongated squirmer rods**

**Arne Zantop and Holger Stark**

Simulations of flow fields around microscopic objects typically require methods that both solve the Navier–Stokes equations and also include thermal fluctuations. One such method popular in the field of soft-matter physics is the particle-based simulation method of multi-particle collision dynamics (MPCD). However, in contrast to the typically incompressible real fluid, the fluid of the traditional MPCD methods obeys the ideal-gas equation of state. This can be problematic because most fluid properties strongly depend on the fluid density. In a recent article, we proposed an extended MPCD algorithm and derived its non-ideal equation of state and an expression for the viscosity. In the present work, we demonstrate its accuracy and efficiency for the simulations of the flow fields of single squirmers and of the collective dynamics of squirmer rods. We use two exemplary squirmer-rod systems for which we compare the outcome of the extended MPCD method to the well-established MPCD version with an Andersen thermostat. First, we explicitly demonstrate the reduced compressibility of the MPCD fluid in a cluster of squirmer rods. Second, for shorter rods, we show the interesting result that in simulations with the extended MPCD method, dynamic swarms are more pronounced and have a higher polar order. Finally, we present a thorough study of the state diagram of squirmer rods moving in the center plane of a Hele-Shaw geometry. From a small to large aspect ratio and density, we observe a disordered state, dynamic swarms, a single swarm, and a jammed cluster, which we characterize accordingly.

J. Chem. Phys. **155**, 134904 (2021)

**Mechanical pressure and work cycle of confined active Brownian particles**

**Paolo Malgaretti, Piotr Nowakowski, and Holger Stark**

We derive an analytic expression for the mechanical pressure of a generic one-dimensional model of confined active Brownian particles (ABPs) that is valid for all values of Péclet number Pe and all confining scenarios. Our model reproduces the known scaling of bulk pressure with Pe² while in strong confinement pressure scales with Pe² . Our analytic results are very well reproduced by simulations of ABPs in 2D. We use the pressure formula to calculate both the work performed by an active engine and its efficiency. In particular, efficiency is maximized for work cycles with finite period and not in the limit of infinitely slow cycles as in thermodynamic engines.

Europhys. Lett. **134**, 20002 (2021)

**A Pair of Particles in Inertial Microfluidics: Effect of Shape, Softness, and Position**

**Kuntal Patel and Holger Stark**

Lab-on-a-chip devices based on inertial microfluidics have emerged as a promising technique to manipulate particles in a precise way. Inertial microfluidics exploits internal hydrodynamic forces and the mechanical structure of particles to achieve separation and focusing. The article focuses on the hydrodynamic interaction of two particles. This will help to develop an understanding of the dynamics of particle trains in inertial microfluidics, which are typical structures in multi-particle systems. We perform three-dimensional lattice Boltzmann simulations combined with the immersed boundary method to unravel the dynamics of various mono- and bi-dispersed pairs in inertial microfluidics. We study the influence of different starting positions for mono- and bi-dispersed pairs. We also change their deformability from relatively soft to rigid and choose spherical and biconcave particle shapes. The observed two-particle motions in the present work can be categorized into four types: stable pair, stable pair with damped oscillations, stable pair with bounded oscillations, and unstable pair. We show that stable pairs become unstable when increasing the particle stiffness. Furthermore, a pair with both capsules in the same channel half is more prone to become unstable than a pair with capsules in opposite channel halves.

**Multi-Particle Collision Dynamics with a Non-Ideal Equation of State: Part I**

**Arne Zantop and Holger Stark**

The method of multi-particle collision dynamics (MPCD) and its different implementations are commonly used in the field of soft matter physics to simulate fluid flow at the micron scale. Typically, the coarse-grained fluid particles are described by the equation of state of an ideal gas, and the fluid is rather compressible. This is in contrast to conventional fluids, which are incompressible for velocities much below the speed of sound, and can cause inhomogeneities in density. We propose an algorithm for MPCD with a modified collision rule that results in a non-ideal equation of state and a significantly decreased compressibility. It allows simulations at less computational costs compared to conventional MPCD algorithms. We derive analytic expressions for the equation of state and the corresponding compressibility as well as shear viscosity. They show overall very good agreement with simulations, where we determine the pressure by simulating a quiet bulk fluid and the shear viscosity by simulating a linear shear flow and a Poiseuille flow.

J. Chem. Phys. **154**, 024105 (2021)

**Effective Langevin equations for a polar tracer in an active bath**

**by Milos Knezevic and Holger Stark**

We study the motion of a polar tracer, having a concave surface, immersed in a two-dimensional suspension of active particles. Using Brownian dynamics simulations, we measure the distributions and auto-correlation functions of force and torque exerted by active particles on the tracer. The tracer experiences a finite average force along its polar axis, while all the correlation functions show exponential decay in time. Using these insights we construct the full coarse-grained Langevin description for tracer position and orientation, where the active particles are subsumed into an effective self-propulsion force and exponentially correlated noise for both translations and rotations. The ensuing mesoscopic dynamics can be described in terms of five dimensionless parameters. We perform a thorough parameter study of the mean squared displacement, which illustrates how the different parameters influence the tracer dynamics, which crosses over from a ballistic to diffusive motion. We also demonstrate that the distribution of tracer displacements evolves from a non-Gaussian shape at early stages to a Gaussian behavior for sufficiently long times. Finally, for a given set of microscopic parameters, we establish a procedure to estimate the matching parameters of our effective model, and show that the resulting dynamics is in a very good quantitative agreement with the one obtained in Brownian dynamics simulations.

New J. Phys. **22**, 113025 (2020)

**Active open-loop control of elastic turbulence**

**by Reinier van Buel and Holger Stark**

We demonstrate through numerical solutions of the Oldroyd-B model in a two-dimensional Taylor–Couette geometry that the onset of elastic turbulence in a viscoelastic fluid can be controlled by imposed shear-rate modulations, one form of active open-loop control. Slow modulations display rich and complex behavior where elastic turbulence is still present, while it vanishes for fast modulations and a laminar response with the Taylor–Couette base flow is recovered. We find that the transition from the laminar to the turbulent state is supercritical and occurs at a critical Deborah number. In the state diagram of both control parameters, Weissenberg versus Deborah number, we identify the region of elastic turbulence. We also quantify the transition by the flow resistance, for which we derive an analytic expression in the laminar regime within the linear Oldroyd-B model. Finally, we provide an approximation for the transition line in the state diagram introducing an effective critical Weissenberg number in comparison to constant shear. Deviations from the numerical result indicate that the physics behind the observed laminar-to-turbulent transition is more complex under time-modulated shear flow.

Sci. Rep. **10**, 15704 (2020)

**Particle pairs and trains in inertial microfluidics**

**by Christian Schaaf and Holger Stark**

Staggered and linear multi-particle trains constitute characteristic structures in inertial microfluidics. Using lattice-Boltzmann simulations, we investigate their properties and stability, when flowing through microfluidic channels. We confirm the stability of cross-streamline pairs by showing how they contract or expand to their equilibrium axial distance. In contrast, same-streamline pairs quickly expand to a characteristic separation but even at long times slowly drift apart. We reproduce the distribution of particle distances with its characteristic peak as measured in experiments. Staggered multi-particle trains initialized with an axial particle spacing larger than the equilibrium distance contract non-uniformly due to collective drag reduction. Linear particle trains, similar to pairs, rapidly expand toward a value about twice the equilibrium distance of staggered trains and then very slowly drift apart non-uniformly. Again, we reproduce the statistics of particle distances and the characteristic peak observed in experiments. Finally, we thoroughly analyze the damped displacement pulse traveling as a microfluidic phonon through a staggered train and show how a defect strongly damps its propagation.

Eur. Phys. J. E **43**, 50 (2020).

selected for front cover picture

**Optimal Control of Colloidal Trajectories in Inertial Microfluidics Using the Saffman Effect**

**by Felix Rühle, Christian Schaaf, and Holger Stark**

In inertial microfluidics colloidal particles in a Poiseuille flow experience the Segré-Silberberg lift force, which drives them to specific positions in the channel cross section. An external force applied along the microchannel induces a cross-streamline migration to a new equilibrium position because of the Saffman effect. We apply optimal control theory to design the time protocol of the axial control force in order to steer a single particle as precisely as possible from a channel inlet to an outlet at a chosen target position. We discuss the influence of particle radius and channel length and show that optimal steering is cheaper than using a constant control force. Using a single optimized control-force protocol, we demonstrate that even a pulse of particles spread along the channel axis can be steered to a target and that particles of different radii can be separarted most efficiently.

**Squirmer rods as elongated microswimmers: flow fields and confinement**

**by Arne W. Zantop and Holger Stark**

Microswimmers or active elements, such as bacteria and active filaments, have an elongated shape, which determines their individual and collective dynamics. There is still a need to identify what role long-range hydrodynamic interactions play in their fascinating dynamic structure formation. We construct rods of different aspect ratios using several spherical squirmer model swimmers. With the help of the mesoscale simulation method of multi-particle collision dynamics we analyze the flow fields of these squirmer rods both in a bulk fluid and in Hele-Shaw geometries of different slab widths. Based on the hydrodynamic multipole expansion either for bulk or confinement between two parallel plates, we categorize the different multipole contributions of neutral as well as pusher-type squirmer rods. We demonstrate how confinement alters the radial decay of the flow fields for a given force or source multipole moment compared to the bulk fluid.

**Emergent collective dynamics of bottom-heavy squirmers under gravity**

**by Felix Rühle and Holger Stark**

We present the results of hydrodynamic simulations using the method of multi-particle collision dynamics for a system of squirmer microswimmers moving under the influence of gravity at low Reynolds numbers. In addition, the squirmers are bottom-heavy so that they experience a torque which aligns them along the vertical. The squirmers interact hydrodynamically by the flow fields of a stokeslet and rotlet, which are initiated by the acting gravitational force and torque, respectively, and by their own flow fields. By varying the ratio of swimming to bulk sedimentation velocity and the torque, we determine state diagrams for the emergent collective dynamics of neutral squirmers as well as strong pushers and pullers. For low swimming velocity and torque we observe conventional sedimentation, while the sedimentation profile becomes inverted when their values are increased. For neutral squirmers we discover convective rolls of circulating squirmers between both sedimentation states, which sit at the bottom of the system and are fed by plumes made of collectively sinking squirmers. At larger torques porous clusters occur that spawn single squirmers. The two latter states can also occur transiently starting from a uniform squirmer distribution and then disappear in the long-time limit. For strong pushers and pullers only weak plume formation is observed.

Eur. Phys. J. E **43**, 26 (2020)

see also: *'Bottom-heavy' squirmers adopt characteristic group behaviours*, article as EPJE Highlight and at EurekAlert

**Capillary condensation in an active bath**

**by Milos Knezevic and Holger Stark**

e study capillary condensation in a bath of active Brownian particles (ABPs) and the forces acting on the capillary close to the motility-induced phase separation (MIPS). The capillary is modeled as two parallel rods, which are fixed in space. We consider a bath of ABPs having a self-propulsion speed much larger than the critical speed necessary for MIPS to occur.We gradually increase the packing fraction of ABPs, starting from a dilute phase of ABPs and going towards the binodal of MIPS. In stark contrast to conventional capillary condensation, we do not observe any hysteresis in the capillary packing fraction and attribute this to strong temporal fluctuations in the capillary packing fraction . Depending on the packing fraction of ABPs and capillary width, we find that the effective force between the capillary rods can be either attractive or repulsive. In fact,with increasing width it shows damped oscillations as long as capillary condensation occurs. We analyze them in detail by studying the distribution of particle distances from the inner and outer wall of the capillary, respectively. In addition, we examine the capillary in the active bath close to the critical point. We do not observe signs of the presence of long-range Casimir interactions.

Europhys. Lett. **128**, 40008 (2020)

**A flowing pair of particles in inertial microfluidics**

**by Christian Schaaf, Felix Rühle and Holger Stark**

A flowing pair of particles in inertial microfluidics gives important insights into understanding and controlling the collective dynamics of particles like cells or droplets in microfluidic devices. They are applied in medical cell analysis and engineering. We study the dynamics of a pair of solid particles flowing through a rectangular microchannel using lattice Boltzmann simulations. We determine the inertial lift force profiles as a function of the two particle positions, their axial distance, and the Reynolds number. Generally, the profiles strongly differ between particles leading and lagging in flow and the lift forces are enhanced due to the presence of a second particle. At small axial distances, they are determined by viscous forces, while inertial forces dominate at large separations. We identify cross-streamline pairs as stable fixed points in the lift force profiles and argue that same-streamline configurations are only one-sided stable. Depending on the initial conditions, the two-particle lift forces in combination with the Poiseuille flow give rise to three types of unbound particle trajectories, called moving-apart, passing, and swapping, and one type of bound trajectory, where the particles perform damped oscillations towards the cross-stream line configuration. The damping rate scales with Reynolds number squared, since inertial forces are responsible for driving the particles to their steady-state positions.

Soft Matter **15**, 1988 (2019)

**Traveling concentration pulses of bacteria in a generalized Keller–Segel model**

**by Maximilian Seyrich, Andrzej Palugniok, and Holger Stark**

We formulate a Markovian response theory for the tumble rate of a bacterium moving in a chemical field and use it in the Smoluchowski equation. Based on a multipole expansion for the one-particle distribution function and a reaction-diffusion equation for the chemoattractant field, we derive a polarization extended model, which also includes the recently discovered angle bias. In the adiabatic limit we recover a generalized Keller–Segel equation with diffusion and chemotactic coefficients that depend on the microscopic swimming parameters. Requiring the tumble rate to be positive, our model introduces an upper bound for the chemotactic drift velocity, which is no longer singular as in the original Keller–Segel model. Solving the Keller–Segel equations numerically, we identify traveling bacterial concentration pulses, for which we do not need a second, signaling chemical field nor a singular chemotactic drift velocity as demanded in earlier publications. We present an extensive study of the traveling pulses and demonstrate how their speeds, widths, and heights depend on the microscopic parameters. Most importantly, we discover a maximum number of bacteria that the pulse can sustain—the maximum carrying capacity. Finally, by tuning our parameters, we are able to match the experimental realization of the traveling bacterial pulse.

New J. Phys. **21, **103001 (2019)

**Chemotaxis in a binary mixture of active and passive particles**

**by Julian Stürmer , Maximilian Seyrich , and Holger Stark**

Mixtures of active and passive colloids show an intriguing dynamics of self-assembling, which is driven by the active component. Self-phoretic active colloids generate sinks in a chemical concentration field that cause passive colloids to drift toward active colloids by diffusiophoresis. The strength of this effective attraction is governed by the diffusiophoretic parameter, which determines the drift velocity. Simulating the Langevin dynamics of the colloids, we determine the state diagram for increasing diffusiophoretic strength and fixed active velocity. Three main states are distinguished. For weak attraction, passive particles are first scattered in the simulation box and then form a colloidal cloud around its center. Increasing the diffusiophoretic parameter further, passive particles oscillate between the cloud and a compact cluster, which embeds active colloids. Ultimately, in the third state, all particles collapse into a single stable cluster. In the collapse regime, the clustering dynamics of the largest cluster follows a logistic function and the mean cluster velocity vs cluster size decays with a power law. Throughout this article, we discuss our simulation results with regard to the experiments of Singh et al., Adv. Mater. **29** (32), 1701328 (2017).

J. Chem. Phys. **150**, 214901 (2019)

**Optimal steering of a smart active particle**

**by Elias Schneider and Holger Stark**

We formulate the theory for steering an active particle with optimal travel time between two locations and apply it to the Mexican hat potential without brim. For small heights the particle can cross the potential barrier, while for large heights it has to move around it. Thermal fluctuations in the orientation strongly affect the path over the barrier. Then we consider a smart active particle and apply reinforcement learning. We show how the active particle learns in repeating episodes to move optimally. The optimal steering is stored in the optimized action-value function, which is able to rectify thermal fluctuations.

**Collective Dynamics in a Monolayer of Squirmers Confined to a Boundary by Gravity**

**by Jan-Timm Kuhr, Felix Rühle, and Holger Stark**

We present a hydrodynamic study of a monolayer of squirmer model microswimmers confined to aboundary by strong gravity using the simulation method of multi-particle collision dynamics. Thesquirmers interact with each other via their self-generated hydrodynamic flow fields and thereby form avariety of fascinating dynamic states when density and squirmer type are varied. Weak pushers, neutralsquirmers, and pullers have an upright orientation. With their flow fields they push neighbors away andthereby form a hydrodynamic Wigner fluid at lower densities. Furthermore, states of fluctuating chainsand trimers, of kissing, and at large densities a global cluster exist. Finally, pushers at all densities can tiltagainst the wall normal and their in-plane velocities align to show swarming. It turns into chaoticswarming for strong pushers at high densities. We characterize all these states quantitatively.

Soft Matter **15**, 5685 (2019)

**Artificial Chemotaxis of Self-Phoretic Active Colloids: Collective Behavior**

**by Holger Stark**

Microorganisms use chemotaxis, regulated by internal complex chemical pathways, to swim along chemical gradients to find better living conditions. Artificial microswimmers can mimic such a strategy by a pure physical process called diffusiophoresis, where they drift and orient along the gradient in a chemical density field. Similarly, for other forms of taxis in nature such as photo- or thermotaxis the phoretic counterpart exists.

In this Account, we concentrate on the chemotaxis of self-phoretic active colloids. They are driven by self-electro- and diffusiophoresis at the particle surface and thereby acquire a swimming speed. During this process, they also produce nonuniform chemical fields in their surroundings through which they interact with other colloids by translational and rotational diffusiophoresis. In combination with active motion, this gives rise to effective phoretic attraction and repulsion and thereby to diverse emergent collective behavior. A particular appealing example is dynamic clustering in dilute suspensions first reported by a group from Lyon. A subtle balance of attraction and repulsion causes very dynamic clusters, which form and resolve again. This is in stark contrast to the relatively static clusters of motility-induced phase separation at larger densities.

To treat chemotaxis in active colloids confined to a plane, we formulate two Langevin equations for position and orientation, which include translational and rotational diffusiophoretic drift velocities. The colloids are chemical sinks and develop their long-range chemical profiles instantaneously. For dense packings, we include screening of the chemical fields. We present a state diagram in the two diffusiophoretic parameters governing translational, as well as rotational, drift and, thereby, explore the full range of phoretic attraction and repulsion. The identified states range from a gaslike phase over dynamic clustering states 1 and 2, which we distinguish through their cluster size distributions, to different types of collapsed states. The latter include a full chemotactic collapse for translational phoretic attraction. Turning it into an effective repulsion, with increasing strength first the collapsed cluster starts to fluctuate at the rim, then oscillates, and ultimately becomes a static collapsed cloud. We also present a state diagram without screening. Finally, we summarize how the famous Keller−Segel model derives from our Langevin equations through a multipole expansion of the full one-particle distribution function in position and orientation. The Keller−Segel model gives a continuum equation for treating chemotaxis of microorganisms on the level of their spatial density.

Our theory is extensible to mixtures of active and passive particles and allows to include a dipolar correction to the chemical field resulting from the dipolar symmetry of Janus colloids.

Acc. Chem. Res. **51**, 2681 (2018)

**Elastic turbulence in two-dimensional Taylor-Couette flows **

**by R. van Buel, C. Schaaf, and H. Stark**

We report the onset of elastic turbulence in a two-dimensional Taylor-Couette geometry using numerical solutions of the Oldroyd-B model generated with the program OpenFOAM®. Beyond a critical Weissenberg number, an elastic instability causes a supercritical transition from the laminar Taylor-Couette flow to a turbulent flow. The order parameter, the time average of secondary-flow strength, follows the scaling law Φ∝ Wi -Wi_{c}^{γ} with Wi_{c}=10 and γ= 0.45 . Additionally, the flow resistance increases beyond Wi_{c} . The temporal power spectra of the velocity fluctuations show a power-law decay with a characteristic exponent in the range 2< α < 4 , which strongly depends on the radial position. The characteristic exponent β for the spatial power spectra obeys the necessary condition β > 3 , associated with elastic turbulence, for all Wi > Wi_{c} .

Europhys. Lett. **124,** 14001 (2018)

**Feedback control of photoresponsive fluid interfaces**

**by Josua Grawitter and Holger Stark**

Photoresponsive surfactants provide a unique microfluidic driving mechanism. Since they switch between two molecular shapes under illumination and thereby affect surface tension of fluid interfaces, Marangoni flow along the interface occurs. To describe the dynamics of the surfactant mixture at a planar interface, we formulate diffusion–advection–reaction equations for both surfactant densities. They also include adsorption from and desorption into the neighboring fluids and photoisomerization by light. We then study how the interface responds when illuminated by spots of light. Switching on a single light spot, the density of the switched surfactant spreads in time and assumes an exponentially decaying profile in steady state. Simultaneously, the induced radial Marangoni flow reverses its flow direction from inward to outward. We use this feature to set up specific feedback rules, which couple the advection velocities sensed at the light spots to their intensities. As a result two neighboring spots switch on and off alternately. Extending the feedback rule to light spots arranged on the vertices of regular polygons, we observe periodic switching patterns for even-sided polygons, where two sets of next-nearest neighbors alternate with each other. A triangle and pentagon also show regular oscillations, while heptagon and nonagon exhibit irregular oscillations due to frustration. While our findings are specific to the chosen set of parameters, they show how complex patterns at photoresponsive fluid interfaces emerge from simple feedback coupling.

Soft Matter **14**, 1856 (2018)